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A Bactericidal Guanidinomethyl Biaryl That Alters the Dynamics of Bacterial FtsZ Polymerization

[Image: see text] The prevalence of multidrug resistance among clinically significant bacterial pathogens underscores a critical need for the development of new classes of antibiotics with novel mechanisms of action. Here we describe the synthesis and evaluation of a guanidinomethyl biaryl compound...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kaul, Malvika, Parhi, Ajit K., Zhang, Yongzheng, LaVoie, Edmond J., Tuske, Steve, Arnold, Eddy, Kerrigan, John E., Pilch, Daniel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969268/
https://ncbi.nlm.nih.gov/pubmed/23050700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3012728
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