Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation

Bivalirudin is a direct thrombin inhibitor that is increasingly used in percutaneous coronary intervention (PCI) and has been previously shown to lack inherent platelet activation. Thrombin works through activation of protease activated receptor-1 (PAR1) and PAR4 on human platelets to initiate signa...

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Hauptverfasser: Holinstat, Michael, Colowick, Nancy E., Hudson, Willie J., Blakemore, Dana, Chen, Qingxia, Hamm, Heidi E., Cleator, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969264/
https://ncbi.nlm.nih.gov/pubmed/23054462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11239-012-0812-9
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