Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease()

Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death. In rodents, inhibition of this pathway causes selective dopaminergic cell death leading...

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Detalhes bibliográficos
Main Authors: Dunn, Laura, Allen, George FG., Mamais, Adamantios, Ling, Helen, Li, Abi, Duberley, Kate E., Hargreaves, Iain P., Pope, Simon, Holton, Janice L., Lees, Andrew, Heales, Simon J., Bandopadhyay, Rina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969149/
https://ncbi.nlm.nih.gov/pubmed/24300239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.11.001
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