The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors

BACKGROUND AND PURPOSE: Here, we describe the in vitro and in vivo effects of (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide (E1R), a novel positive allosteric modulator of sigma-1 receptors. EXPERIMENTAL APPROACH: E1R was tested for sigma receptor binding activity in a [(3)H](+)-pent...

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Detalhes bibliográficos
Main Authors: Zvejniece, L, Vavers, E, Svalbe, B, Vilskersts, R, Domracheva, I, Vorona, M, Veinberg, G, Misane, I, Stonans, I, Kalvinsh, I, Dambrova, M
Formato: Artigo
Idioma:Inglês
Publicado em: British Journal of Pharmacology 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969087/
https://ncbi.nlm.nih.gov/pubmed/24490863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12506
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