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Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and complicated by the physiology of the mammalian neu...

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Bibliografiske detaljer
Main Authors: Lorenzini, Antonello, Salmon, Adam B., Lerner, Chad, Torres, Claudio, Ikeno, Yuji, Motch, Susan, McCarter, Roger, Sell, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968822/
https://ncbi.nlm.nih.gov/pubmed/23873963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt108
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