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Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I
The extension of lifespan due to reduced insulin-like growth factor 1 (IGF-I) signaling in mice has been proposed to be mediated through alterations in metabolism. Previously, we showed that mice homozygous for an insertion in the Igf1 allele have reduced levels of IGF-I, are smaller, and have an ex...
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| Udgivet i: | Am J Physiol Endocrinol Metab |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4385875/ https://ncbi.nlm.nih.gov/pubmed/25648834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00558.2014 |
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