Strain- and Age-dependent Hippocampal Neuron Sodium Currents Correlate with Epilepsy Severity in Dravet Syndrome Mice

Heterozygous loss-of-function SCN1A mutations cause Dravet syndrome, an epileptic encephalopathy of infancy that exhibits variable clinical severity. We utilized a heterozygous Scn1a knockout (Scn1a(+/−)) mouse model of Dravet syndrome to investigate the basis for phenotype variability. These animal...

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Huvudupphovsmän: Mistry, Akshitkumar M., Thompson, Christopher H., Miller, Alison R., Vanoye, Carlos G., George, Alfred L., Kearney, Jennifer A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968814/
https://ncbi.nlm.nih.gov/pubmed/24434335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.01.006
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