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IRE1α is essential for Xenopus pancreas development
Inositol requiring enzyme-1 (IRE1) is highly conserved from yeasts to humans. Upon the endoplasmic reticulum (ER) stress, IRE1 activates X-box-binding protein 1 (XBP1) by unconventionally splicing XBP1 mRNA, which activates the unfolded protein response (UPR) to restore ER homeostasis. In mice, IRE1...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Editorial Department of Journal of Biomedical Research
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3968283/ https://ncbi.nlm.nih.gov/pubmed/24683410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.28.20130076 |
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