Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic colorectal cancer (CRC). However, almost all patients with clinical response to anti-EGFR therapies show disease progression wit...

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Hlavní autoři: Mohan, Sumitra, Heitzer, Ellen, Ulz, Peter, Lafer, Ingrid, Lax, Sigurd, Auer, Martina, Pichler, Martin, Gerger, Armin, Eisner, Florian, Hoefler, Gerald, Bauernhofer, Thomas, Geigl, Jochen B., Speicher, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967949/
https://ncbi.nlm.nih.gov/pubmed/24676216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004271
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