An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

The antigenic repertoire presented by MHC molecules is generated by the antigen processing and presentation (APP) pathway. We analyzed the evolutionary history of 45 genes involved in APP at the inter- and intra-species level. Results showed that 11 genes evolved adaptively in mammals. Several posit...

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Détails bibliographiques
Auteurs principaux: Forni, Diego, Cagliani, Rachele, Tresoldi, Claudia, Pozzoli, Uberto, De Gioia, Luca, Filippi, Giulia, Riva, Stefania, Menozzi, Giorgia, Colleoni, Marta, Biasin, Mara, Lo Caputo, Sergio, Mazzotta, Francesco, Comi, Giacomo P., Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967941/
https://ncbi.nlm.nih.gov/pubmed/24675550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004189
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