The signature of long-standing balancing selection at the human defensin β-1 promoter

BACKGROUND: Defensins, small endogenous peptides with antimicrobial activity, are pivotal components of the innate immune response. A large cluster of defensin genes is located on human chromosome 8p; among them the beta defensin 1 (DEFB1) promoterhas been extensively studied since discovery that sp...

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Autori principali: Cagliani, Rachele, Fumagalli, Matteo, Riva, Stefania, Pozzoli, Uberto, Comi, Giacomo P, Menozzi, Giorgia, Bresolin, Nereo, Sironi, Manuela
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592704/
https://ncbi.nlm.nih.gov/pubmed/18817538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-9-r143
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