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Novel Triaryl Sulfonamide Derivatives as Selective Cannabinoid Receptor 2 Inverse Agonist and Osteoclast Inhibitor: Discovery, Optimization and Biological Evaluation

Cannabinoid receptors have gained more and more attention as drug targets for developing potential therapeutic ligands. Here, we report the discovery and optimization of triaryl sulfonamide as a novel series possessing significant CB(2) receptor affinity and selectivity. Four sets of triaryl ligands...

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Detalhes bibliográficos
Main Authors: Yang, Peng, Wang, Liping, Feng, Rentian, Almehizia, Abdulrahman A., Tong, Qin, Myint, Kyaw-Zeyar, Ouyang, Qin, Alqarni, Mohammed Hamed, Wang, Lirong, Xie, Xiang-Qun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967766/
https://ncbi.nlm.nih.gov/pubmed/23406429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3017464
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