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Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy
To enhance silencing and avoid off-target effects, siRNAs are often designed with an intentional bias to ensure that the end of the siRNA that contains the guide strand 5′ end is less stably hybridized relative to the end containing the passenger strand 5′ end. One means by which this is accomplishe...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3967519/ https://ncbi.nlm.nih.gov/pubmed/19811537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07364.x |
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