The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells

Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs); however since Notch-deficient embryos die early in gestation, additional functions for Notch in embryonic HSC biology have not been described. We used two complementary genetic models to address this important bio...

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Hlavní autoři: Gerhardt, Dawson M., Pajcini, Kostandin V., D’altri, Teresa, Tu, LiLi, Jain, Rajan, Xu, Lanwei, Chen, Michael J., Rentschler, Stacey, Shestova, Olga, Wertheim, Gerald B., Tobias, John W., Kluk, Michael, Wood, Antony W., Aster, Jon C., Gimotty, Phyllis A., Epstein, Jonathan A., Speck, Nancy, Bigas, Anna, Pear, Warren S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967047/
https://ncbi.nlm.nih.gov/pubmed/24637115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.227496.113
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