Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo

BACKGROUND AND PURPOSE: The transcription factor NF-κB orchestrates many pro-inflammatory signals and its inhibition is considered a promising strategy to combat inflammation. Here we report the characterization of the natural product plumericin as a highly potent inhibitor of the NF-κB pathway with...

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Bibliographic Details
Main Authors: Fakhrudin, N, Waltenberger, B, Cabaravdic, M, Atanasov, A G, Malainer, C, Schachner, D, Heiss, E H, Liu, R, Noha, S M, Grzywacz, A M, Mihaly-Bison, J, Awad, E M, Schuster, D, Breuss, J M, Rollinger, J M, Bochkov, V, Stuppner, H, Dirsch, V M
Format: Artigo
Language:Inglês
Published: John Wiley & Sons Ltd 2014
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966748/
https://ncbi.nlm.nih.gov/pubmed/24329519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12558
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