Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation

The etiology of atherosclerosis and restenosis involves aberrant inflammation and proliferation, rendering compounds with both anti-inflammatory and anti-mitogenic properties as promising candidates for combatting vascular diseases. A recent study identified the iridoid plumericin as a new scaffold...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Heiss, Elke H, Liu, Rongxia, Waltenberger, Birgit, Khan, Shafaat, Schachner, Daniel, Kollmann, Paul, Zimmermann, Kristin, Cabaravdic, Muris, Uhrin, Pavel, Stuppner, Hermann, Breuss, Johannes M, Atanasov, Atanas G, Dirsch, Verena M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746734/
https://ncbi.nlm.nih.gov/pubmed/26858089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20771
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