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Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins

The liver plays a central role in metabolism and mediating insulin action. To dissect the effects of insulin on the liver in vivo, we have studied liver insulin receptor knockout (LIRKO) mice. Because LIRKO livers lack insulin receptors, they are unable to respond to insulin. Surprisingly, the most...

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Autors principals: Miao, Ji, Haas, Joel T., Manthena, Praveen, Wang, Yanning, Zhao, Enpeng, Vaitheesvaran, Bhavapriya, Kurland, Irwin J., Biddinger, Sudha B.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966700/
https://ncbi.nlm.nih.gov/pubmed/24516236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M043711
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