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Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous attempts to inhibit the protein and restore t...

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Bibliografiske detaljer
Main Authors: Callaghan, Richard, Luk, Frederick, Bebawy, Mary
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965902/
https://ncbi.nlm.nih.gov/pubmed/24492893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.056176
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