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Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous attempts to inhibit the protein and restore t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965902/ https://ncbi.nlm.nih.gov/pubmed/24492893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.056176 |
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