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Eudistomin D and Penaresin Derivatives as Modulators of Ryanodine Receptor Channels and Sarcoplasmic Reticulum Ca(2+) ATPase in Striated Muscle

Eudistomin D (EuD) and penaresin (Pen) derivatives are bioactive alkaloids from marine sponges found to induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR). Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a “caffeine-like” manner, no single-chann...

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Detalhes bibliográficos
Main Authors: Diaz-Sylvester, Paula L., Porta, Maura, Juettner, Vanessa V., Lv, Yuanzhao, Fleischer, Sidney, Copello, Julio A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965891/
https://ncbi.nlm.nih.gov/pubmed/24423447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.089342
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