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The molecular basis for an ancient partnership between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2
Pin1 is a prolyl isomerase that recognizes phosphorylated Ser/Thr-Pro sites and phosphatase inhibitor-2 (I-2) is phosphorylated during mitosis at a PSpTP site that is expected to be a Pin1 substrate. However, we previously discovered I-2, but not phospho-I-2, bound to Pin1 as an allosteric modifier...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965691/ https://ncbi.nlm.nih.gov/pubmed/21714498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200553e |
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