Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction

BACKGROUND: Introduction of the yellow obese gene (A(y)) into mice (KKAy) results in obesity and diabetes by 5 weeks of age. METHODS: Using this model of type 2 diabetes, we evaluated male and female 6–8 month old wild type (WT, n=10) and KKAy (n=22) mice subjected to myocardial infraction (MI) and...

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Hlavní autoři: Heaberlin, James R., Ma, Yonggang, Zhang, Jianhua, Ahuja, Seema S., Lindsey, Merry L., Halade, Ganesh V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965668/
https://ncbi.nlm.nih.gov/pubmed/23896047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2013.06.002
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