Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice

Brain-derived neurotrophic factor (BDNF) increases in failing hearts, but BDNF roles in cardiac remodeling following myocardial infarction (MI) are unclear. Male BDNF(+/+) [wild-type (WT)] and BDNF(+/−) heterozygous (HET) mice at 6–9 mo of age were subjected to MI and evaluated at days 1, 3, 5, 7, o...

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Hlavní autoři: Halade, Ganesh V., Ma, Yonggang, Ramirez, Trevi A., Zhang, Jianhua, Dai, Qiuxia, Hensler, Julie G., Lopez, Elizabeth F., Ghasemi, Omid, Jin, Yu-Fang, Lindsey, Merry L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Integrative Cardiovascular Physiology and Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882541/
https://ncbi.nlm.nih.gov/pubmed/24142413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00224.2013
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