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UNRAVELING THE COMPLEXITY OF NEURODEGENERATION IN BRAIN OF SUBJECTS WITH DOWN SYNDROME: INSIGHTS FROM PROTEOMICS

Down syndrome (DS) is one of the most common genetic cause of intellectual disability characterized by multiple pathological phenotypes, among which neurodegeneration is a key feature. The neuropathology of DS is complex and likely results from impaired mitochondrial function, increased oxidative st...

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Detalhes bibliográficos
Main Authors: Perluigi, Marzia, Di Domenico, Fabio, AllanButtterfield, D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965623/
https://ncbi.nlm.nih.gov/pubmed/24259517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prca.201300066
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