A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp

Mis-sense mutations in the α-subunit of the G-protein, G(s)α, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active G(s)α and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the id...

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Autores principales: Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z., Mathews Griner, Lesley A., Zheng, Wei, Inglese, James, Austin, Christopher P., Marugan, Juan J., Southall, Noel, Neumann, Susanne, Northup, John K., Ferrer, Marc, Collins, Michael T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965391/
https://ncbi.nlm.nih.gov/pubmed/24667240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090766
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