A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp

Mis-sense mutations in the α-subunit of the G-protein, G(s)α, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active G(s)α and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the id...

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Bibliografiska uppgifter
Huvudupphovsmän: Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z., Mathews Griner, Lesley A., Zheng, Wei, Inglese, James, Austin, Christopher P., Marugan, Juan J., Southall, Noel, Neumann, Susanne, Northup, John K., Ferrer, Marc, Collins, Michael T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965391/
https://ncbi.nlm.nih.gov/pubmed/24667240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090766
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