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A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp
Mis-sense mutations in the α-subunit of the G-protein, G(s)α, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active G(s)α and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the id...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965391/ https://ncbi.nlm.nih.gov/pubmed/24667240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090766 |
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