Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation

Several anesthetics have been reported to suppress the transcription of a number of genes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant role in memory consolidation. The purpose of this study was to explore the mechanism of anesthesia-mediated depression in A...

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Main Authors: Whittington, Robert A., Bretteville, Alexis, Virág, László, Emala, Charles W., Maurin, Thomas O., Marcouiller, François, Julien, Carl, Petry, Franck R., El-Khoury, Noura B., Morin, Françoise, Charron, Jean, Planel, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965357/
https://ncbi.nlm.nih.gov/pubmed/24045785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01388
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