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Stalled replication fork repair and misrepair during thymineless death in Escherichia coli

Starvation for DNA precursor dTTP, known as ‘thymineless death’ (TLD), kills bacterial and eukaryotic cells alike. Despite numerous investigations, toxic mechanisms behind TLD remain unknown, although wrong nucleotide incorporation with subsequent excision dominates the explanations. We show that ki...

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Detalhes bibliográficos
Main Authors: Kuong, Kawai J, Kuzminov, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965187/
https://ncbi.nlm.nih.gov/pubmed/20465561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2443.2010.01405.x
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