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Stalled replication fork repair and misrepair during thymineless death in Escherichia coli

Starvation for DNA precursor dTTP, known as ‘thymineless death’ (TLD), kills bacterial and eukaryotic cells alike. Despite numerous investigations, toxic mechanisms behind TLD remain unknown, although wrong nucleotide incorporation with subsequent excision dominates the explanations. We show that ki...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kuong, Kawai J, Kuzminov, Andrei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965187/
https://ncbi.nlm.nih.gov/pubmed/20465561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2443.2010.01405.x
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