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Stalled replication fork repair and misrepair during thymineless death in Escherichia coli

Starvation for DNA precursor dTTP, known as ‘thymineless death’ (TLD), kills bacterial and eukaryotic cells alike. Despite numerous investigations, toxic mechanisms behind TLD remain unknown, although wrong nucleotide incorporation with subsequent excision dominates the explanations. We show that ki...

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Hlavní autoři: Kuong, Kawai J, Kuzminov, Andrei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965187/
https://ncbi.nlm.nih.gov/pubmed/20465561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2443.2010.01405.x
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