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Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H(2)O(2) emitting source under conditions of nutrient overload
Once regarded as “byproducts” of aerobic metabolism, the production of superoxide/H(2)O(2) is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of thiol-containing proteins, collectively referred to as the redox-sensitive...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965186/ https://ncbi.nlm.nih.gov/pubmed/24056031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.09.008 |
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