Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point

The mouse immunoglobulin (IgM) pre-mRNA contains a splicing inhibitor that bears multiple binding sites for the splicing repressor polypyrimidine tract binding protein (PTB). Here we show that the inhibitor directs assembly of an ATP-dependent complex that contains PTB and U1 and U2 small nuclear RN...

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Autors principals: Zheng, Xuexiu, Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Huyn Kyung, Green, Michael R., Shen, Haihong
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964906/
https://ncbi.nlm.nih.gov/pubmed/24572809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043737.113
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