IL-12(hi) Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ—Dependent Apoptosis of Alloreactive CD4(+) T Cells In Vitro and Reduce Lethal Graft-Versus-Host Disease

Rapamycin (RAPA) inhibits the mechanistic target of rapamycin (mTOR), a crucial immune system regulator. Dendritic cells (DC) generated in RAPA (RAPA-DC) enrich for CD4(+) forkhead box p3 (FoxP3(+)) regulatory T cells and induce T cell apoptosis by an unknown mechanism. RAPA-DC also promote experime...

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Detalhes bibliográficos
Main Authors: Stenger, Elizabeth O., Rosborough, Brian R., Mathews, Lisa R., Ma, Huihui, Mapara, Markus Y., Thomson, Angus W., Turnquist, Hēth R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964782/
https://ncbi.nlm.nih.gov/pubmed/24239650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2013.11.007
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