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Synthetic mammalian transgene negative autoregulation
Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. Here, using synthetic circuits stably integrated in human kidney cells, we st...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964311/ https://ncbi.nlm.nih.gov/pubmed/23736683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.27 |
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