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Synthetic mammalian transgene negative autoregulation

Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. Here, using synthetic circuits stably integrated in human kidney cells, we st...

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Bibliografiska uppgifter
Huvudupphovsmän: Shimoga, Vinay, White, Jacob T, Li, Yi, Sontag, Eduardo, Bleris, Leonidas
Materialtyp: Artigo
Språk:Inglês
Publicerad: European Molecular Biology Organization 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964311/
https://ncbi.nlm.nih.gov/pubmed/23736683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.27
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