Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-β peptide (Aβ) is associated with AD. However, identifying new compounds that antagonize the underlying cellular pathologies caused by Aβ has been h...

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Detaylı Bibliyografya
Asıl Yazarlar: Matlack, Kent E. S., Tardiff, Daniel F., Narayan, Priyanka, Hamamichi, Shusei, Caldwell, Kim A., Caldwell, Guy A., Lindquist, Susan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964050/
https://ncbi.nlm.nih.gov/pubmed/24591589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402228111
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