TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells

Transforming growth factor β1 (TGF-β), enriched in the tumor microenvironment and broadly immunosuppressive, inhibits natural killer (NK) cell function by yet-unknown mechanisms. Here we show that TGF-β–treated human NK cells exhibit reduced tumor cytolysis and abrogated perforin polarization to the...

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Hauptverfasser: Donatelli, Sarah S., Zhou, Jun-Min, Gilvary, Danielle L., Eksioglu, Erika A., Chen, Xianghong, Cress, W. Douglas, Haura, Eric B., Schabath, Matthew B., Coppola, Domenico, Wei, Sheng, Djeu, Julie Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964044/
https://ncbi.nlm.nih.gov/pubmed/24586048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319269111
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