Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our method aims at extracting such constraints from rapidly accu...

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Autores principales: Baldassi, Carlo, Zamparo, Marco, Feinauer, Christoph, Procaccini, Andrea, Zecchina, Riccardo, Weigt, Martin, Pagnani, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963956/
https://ncbi.nlm.nih.gov/pubmed/24663061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092721
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