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Gene Expression Analysis of a Panel of Cell Lines That Differentially Restrict HIV-1 CA Mutants Infection in a Cyclophilin A-Dependent Manner
HIV-1 replication is dependent on binding of the viral capsid to the host protein cyclophilin A (CypA). Interference with cyclophilin A binding, either by mutations in the HIV-1 capsid protein (CA) or by the drug cyclosporine A (CsA), inhibits HIV-1 replication in cell culture. Resistance to CsA is...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963944/ https://ncbi.nlm.nih.gov/pubmed/24663101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092724 |
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