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Gene Expression Analysis of a Panel of Cell Lines That Differentially Restrict HIV-1 CA Mutants Infection in a Cyclophilin A-Dependent Manner

HIV-1 replication is dependent on binding of the viral capsid to the host protein cyclophilin A (CypA). Interference with cyclophilin A binding, either by mutations in the HIV-1 capsid protein (CA) or by the drug cyclosporine A (CsA), inhibits HIV-1 replication in cell culture. Resistance to CsA is...

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Detalhes bibliográficos
Main Authors: Shah, Vaibhav B., Aiken, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963944/
https://ncbi.nlm.nih.gov/pubmed/24663101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092724
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