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Lysosome-dependent p300/FOXP3 degradation and limits T(reg) cell functions and enhances targeted therapy against cancers
p300 is one of several acetyltransferases that regulate FOXP3 acetylation and functions. Our recent studies have defined a complex set of histone acetyltransferase interactions which can lead to enhanced or repressed changes in FOXP3 function. We have explored the use of a natural p300 inhibitor, Ga...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963828/ https://ncbi.nlm.nih.gov/pubmed/23644046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2013.04.003 |
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