Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody

The Wilms tumor 1 (WT1) oncoprotein is an intracellular, oncogenic transcription factor that is overexpressed in a wide range of leukemias and solid cancers. RMFPNAPYL (RMF), a WT1-derived CD8(+) T cell human leukocyte antigen (HLA)–A0201 epitope, is a validated target for T cell–based immunotherapy...

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Autori principali: Dao, Tao, Yan, Su, Veomett, Nicholas, Pankov, Dmitry, Zhou, Liang, Korontsvit, Tatyana, Scott, Andrew, Whitten, Joseph, Maslak, Peter, Casey, Emily, Tan, Taochao, Liu, Hong, Zakhaleva, Victoria, Curcio, Michael, Doubrovina, Ekaterina, O’Reilly, Richard J., Liu, Cheng, Scheinberg, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963696/
https://ncbi.nlm.nih.gov/pubmed/23486779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005661
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