טוען...
Targeted Cox2 gene deletion in intestinal epithelial cells decreases tumorigenesis in female, but not male, Apc (Min/+) mice
Mice heterozygous for mutations in the adenomatous polyposis coli gene (Apc+/− mice) develop intestinal neoplasia. Apc+/− tumor formation is thought to be dependent on cyclooxygenase 2 (COX2) expression; both pharmacologic COX2 inhibition and global Cox2 gene deletion reduce the number of intestinal...
שמור ב:
| Main Authors: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963510/ https://ncbi.nlm.nih.gov/pubmed/24268915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.10.009 |
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