Targeted Cox2 gene deletion in intestinal epithelial cells decreases tumorigenesis in female, but not male, Apc (Min/+) mice

Mice heterozygous for mutations in the adenomatous polyposis coli gene (Apc+/− mice) develop intestinal neoplasia. Apc+/− tumor formation is thought to be dependent on cyclooxygenase 2 (COX2) expression; both pharmacologic COX2 inhibition and global Cox2 gene deletion reduce the number of intestinal...

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Bibliografiske detaljer
Main Authors: Cherukuri, Durga P., Ishikawa, Tomo-o, Chun, Patrick, Catapang, Art, Elashoff, David, Grogan, Tristan R., Bugni, James, Herschman, Harvey R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963510/
https://ncbi.nlm.nih.gov/pubmed/24268915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.10.009
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