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Using Joint Utilities of the Times to Response and Toxicity to Adaptively Optimize Schedule-Dose Regimes
A Bayesian two-stage phase I-II design is proposed for optimizing administration schedule and dose of an experimental agent based on the times to response and toxicity in the case where schedules are non-nested and qualitatively different. Sequentially adaptive decisions are based on the joint utili...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963428/ https://ncbi.nlm.nih.gov/pubmed/23957592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.12065 |
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