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Cytotoxicity of Mutant Huntingtin Fragment in Yeast Can Be Modulated by the Expression Level of Wild Type Huntingtin Fragment

[Image: see text] Conflicting reports exist in the literature regarding the role of wild-type huntingtin in determining the toxicity of the aggregated, mutant huntingtin in Huntington’s disease (HD). Some studies report the amelioration of toxicity of the mutant protein in the presence of the wild-t...

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Main Authors: Saleh, Aliabbas Ahmedbhai, Bhadra, Ankan Kumar, Roy, Ipsita
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963126/
https://ncbi.nlm.nih.gov/pubmed/24377263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400171d
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