PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

The peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) interacts with various transcription factors involved in energy metabolism and in the regulation of mitochondrial biogenesis. PGC-1α mRNA levels are reduced in a number of neurodegenerative diseases and contribute to disease p...

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Main Authors: Dumont, Magali, Stack, Cliona, Elipenahli, Ceyhan, Jainuddin, Shari, Launay, Nathalie, Gerges, Meri, Starkova, Natalia, Starkov, Anatoly A., Calingasan, Noel Y., Tampellini, Davide, Pujol, Aurora, Beal, M. Flint
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2014
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963016/
https://ncbi.nlm.nih.gov/pubmed/24398293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-236331
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