Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor

Immune complexes formed between monoclonal antibodies (mAbs) and toxins can neutralize toxicity in vivo by multiple mechanisms. Toxin sequestration and clearance by mAbs may be improved by enhancing their ability to bind to red blood cells (RBCs) through immune adherence. This can be achieved by con...

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Main Authors: Sharma, Rashmi, Zhao, Huiwu, Al-Saleem, Fetweh H., Ubaid, Ahmed Syed, Puligedda, Rama Devudu, Segan, Andrew T., Lindorfer, Margaret A., Bermudez, Rodney, Elias, Adekar, Sharad P., Simpson, Lance L., Taylor, Ronald P., Dessain, Scott K.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962830/
https://ncbi.nlm.nih.gov/pubmed/24184879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2013.09.005
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