Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B

The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and release of nonesterified fatty acids (NEFA) to the circulation. However, long-term niacin treatment leads to a normalization of plasma NEFA level...

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Main Authors: Heemskerk, Mattijs M., van den Berg, Sjoerd A. A., Pronk, Amanda C. M., van Klinken, Jan-Bert, Boon, Mariëtte R., Havekes, Louis M., Rensen, Patrick C. N., van Dijk, Ko Willems, van Harmelen, Vanessa
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2014
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962609/
https://ncbi.nlm.nih.gov/pubmed/24473440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00641.2013
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