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Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism

The assignment of causative genes to noncoding variants identified in genome-wide association studies (GWASs) is challenging. We show how combination of knowledge from gene and pathway databases and chromatin interaction data leads to reinterpretation of published quantitative trait loci for blood m...

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Dades bibliogràfiques
Publicat a:Eur J Hum Genet
Autors principals: Heemskerk, Mattijs M, van Harmelen, Vanessa JA, van Dijk, Ko Willems, van Klinken, Jan Bert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795225/
https://ncbi.nlm.nih.gov/pubmed/26014429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2015.106
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