Inhibition of Calcineurin Abrogates While Inhibition of mTOR Promotes Regulatory T Cell Expansion and Graft-Versus-Host Disease Protection by IL-2 in Allogeneic Bone Marrow Transplantation

Regulatory T cells (Treg)s attenuate excessive immune responses, making their expansion beneficial in immune-mediated diseases including allogeneic bone marrow transplantation (BMT)-associated graft-versus-host disease (GVHD). We have recently reported that Treg expansion does not require phospholip...

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Main Authors: Satake, Atsushi, Schmidt, Amanda M., Nomura, Shosaku, Kambayashi, Taku
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962458/
https://ncbi.nlm.nih.gov/pubmed/24658577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092888
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