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Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition
INTRODUCTION: Antithrombin, the principal inhibitor of coagulation proteases, requires allosteric activation by its physiological cofactor, heparin or heparin sulfate to achieve physiologically permissible rates. This forms the basis of heparin's use as a clinical anticoagulant. However, hepari...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Medknow Publications & Media Pvt Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961949/ https://ncbi.nlm.nih.gov/pubmed/24678194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0976-9668.127282 |
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