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Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition
INTRODUCTION: Antithrombin, the principal inhibitor of coagulation proteases, requires allosteric activation by its physiological cofactor, heparin or heparin sulfate to achieve physiologically permissible rates. This forms the basis of heparin's use as a clinical anticoagulant. However, hepari...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Medknow Publications & Media Pvt Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961949/ https://ncbi.nlm.nih.gov/pubmed/24678194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0976-9668.127282 |
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