Initial Testing (Stage 1) of TAK-701, a humanized hepatocyte growth factor binding antibody, by the Pediatric Preclinical Testing Program

TAK-701 is a humanized antibody that binds hepatocyte growth factor (HGF), thus suppressing c-Met transduced signaling and c-Met dependent proliferation and migration of tumor cells. Six childhood solid tumor xenografts were selected for evaluating TAK-701 based on immunochemical detection of HGF/c-...

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Bibliographic Details
Main Authors: Houghton, Peter J., Kurmasheva, Raushan T., Kolb, E. Anders, Wu, Jianrong, Gorlick, Richard, Maris, John M., Smith, Malcolm A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961752/
https://ncbi.nlm.nih.gov/pubmed/24019233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24756
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