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Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

To avoid genomic instability, cells have developed surveillance mechanisms such as the spindle assembly checkpoint (SAC) and the DNA damage response. ATM and MDC1 are central players of the cellular response to DNA double-strand breaks. Here, we identify a new role for these proteins in the regulati...

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Detalhes bibliográficos
Main Authors: Eliezer, Yifat, Argaman, Liron, Kornowski, Maya, Roniger, Maayan, Goldberg, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961647/
https://ncbi.nlm.nih.gov/pubmed/24509855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532739
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